توضیحات
- What Spironolactone scored tablet is and what it is used for?
The active ingredient of the tablets is Spironolactone. Spironolactone belongs to a particular group of medicines, known as aldosterone antagonists, which inhibit the action of the hormone aldosterone. One of the functions of aldosterone is to ensure that the body retains sodium. It forms part of a system that regulates the balance of fluids and salts in the body. Spironolactone promotes the excretion of urine in patients in whom there is an accumulation of fluid in the tissues (edema) or in the abdominal cavity (ascites) by increasing the amount of sodium (salt) excreted in the urine. Potassium loss as a possible consequence of using certain diuretics is reduced. The antihypertensive effect relies on the excretion of water and salt.
Spironolactone scored tablets may be prescribed by your doctor for the treatment of:
- Accumulation of fluid in the tissues as a result of heart disorders;
- Severe heart failure;
- Raised blood pressure as an adjunct to a salt-free diet and diuretics;
- Certain kidney disorders;
- Accumulation of fluid in the tissues in the abdominal cavity.
- What you need to know before you take Spironolactone scored tablet :
- Do not take Spironolactone scored tablet:
- If you are allergic to spironolactone or any of the other ingredients of this medicine.
- If you suffer from severely impaired kidney function or from a sudden or rapidly deteriorating kidney disease, including cases in which no urine, or very little urine, is being produced.
- If you have low blood sodium levels (hypernatremia).
- If you have hyperkalemia (raised blood potassium levels) or any other conditions associated with hyperkalemia.
- If you are taking potassium-sparing diuretics (including eplerenone) or potassium-supplements, or dual-RAAS blockade with the combination of an angiotensin converting enzyme (ACE) inhibitor and an angiotensin receptor blocker (ARB).
- Warnings and precautions:
Talk to your doctor or pharmacist before taking Spironolactone scored tablets
- If you need to use Spironolactone scored tablets for a long time; your doctor should perform regular follow-up checks (for example on the levels of potassium and sodium in your blood), especially if you are elderly.
- If you have a liver disorder; your doctor should exercise caution when treating you;
- If you have a kidney disorder; your doctor should exercise caution when treating you;
- If you have a raised level of potassium in the blood or impaired kidney function; administration of Spironolactone is not advised.
- If you have severe renal dysfunction which is being simultaneously treated with potassium supplements, since sever hyperkalemia can occur which can result in cardiac arrest (sometimes fatal).
- If you use certain diuretics, called potassium-sparing diuretics (such as amiloride and triamterene); concomitant use with Spironolactone scored tablet is contra-indicated, because the risk of excessively high levels of potassium in the blood (hyperkalemia) is increased.
- In the case of long-term treatment of young patients with Spironolactone scored tablets, your doctor should weigh the advantages carefully against the long-term disadvantages.
- Concomitant administration of Spironolactone Accord with certain medicines, potassium supplements and food rich in potassium may lead to severe hyperkalemia (increased potassium blood level). The symptoms of severe hyperkalemia might include muscle cramps, irregular heart rhythm, diarrhea, nausea, dizziness or headache.
- Other medicines and Spironolactone scored tablet:
Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines, including medicines obtained without a prescription.
- Medicines for high blood pressure including ACE inhibitors, ganglion-blocking drugs
- Other diuretics
- Non-steroidal anti-inflammatory drug (NSAID) such as aspirin or ibuprofen
- Potassium supplements
- Heparin or low molecular weight heparin (medicines used to prevent blood clots)
- Drugs that inhibit blood coagulation (anticoagulants, ‘blood thinners’) noradrenaline (an agent with a stimulant effect on a particular part of the nervous system (sympathomimetic))
- Lithium (used to treat depression)
- Digoxin (used in the treatment of various heart conditions)
- Alcohol, barbiturates or narcotics
- Medicines known to cause hyperkalemia (raised blood potassium levels)
- Cholestyramine (used for reducing cholesterol levels in the blood)
- Corticosteroids, ACTH (prescribed for different epileptic conditions)
- Ammonium chloride (e.g. in liquor ice)
- Cyclosporine
- Trimethoprim and trimethoprim-sulfamethoxazole
- How to take Spironolactone scored tablet:
Always take this medicine exactly as your doctor or pharmacist has told you. Check with your doctor or pharmacist if you are not sure. You should take the tablets with meals. If the total dose is more than 100 mg per day, the dose must be administered in divided doses spread throughout the day. Remember to take your medicine. Taking your tablets at the same time each day gives the best effect. It also helps you remember when you should take the tablets.
- Possible side effects of Spironolactone scored tablet:
Like all medicines, this medicine can cause side effects, although not everybody gets them.
The side effects depend on the dose and the duration of treatment. The most common side effects are hyperkalemia, reproductive system and breast disorders, including gynaecomastia. Gynaecomastia appears to be related to both dosage level and duration of therapy and is usually reversible as soon as the treatment is discontinued. Other very common undesirable side effects are headache, digestive disturbances, diarrhea, fatigue and drowsiness.
- How to store Spironolactone scored tablet:
– Keep this medicine out of the sight and reach of children.
– This medicinal product does not require any special temperature storage conditions. Store in the original package in order to protect from light.
– Do not use this medicine after the expiry date which is stated on the carton and blister after ‘EXP’.
– The expiry date refers to the last day of that month.
